IgG Subclass Deficiency
20%
1 / 5
Which of the following antibody concentrations must be normal for the patient to qualify for the diagnosis of IgG Subclass Deficiency?
Explanation : By definition, an IgG subclass deficiency diagnosis requires a decrease in 1 or more IgG subclasses and a normal total IgG concentration.
References
Knutsen A. IgG subclass deficiency. In: UpToDate, Post TW (Ed), Wolters Kluwer. https://www.uptodate.com (Accessed on March 8, 2023.), Petrak, R. IgG Subclass Deficiency; Priv Pract Inf Disease (in review)
40%
2 / 5
Which IgG subclass accounts for the majority of the total IgG concentration?
Explanation : IgG 1 accounts for approximately 70% of total IgG. Subsequently, it is uncommon to identify an isolated IgG 1 deficiency with a total IgG normal concentration.
References
Knutsen A. IgG subclass deficiency. In: UpToDate, Post TW (Ed), Wolters Kluwer. https://www.uptodate.com (Accessed on March 8, 2023.), Petrak, R. IgG Subclass Deficiency; Priv Pract Inf Disease (in review)
60%
3 / 5
The IgG subclass primarily responsible for the antibody response to polysaccharide capsular antigens is ___ ?
Explanation : IgG 2 is the principle subclass responsible for response to polysaccharide capsular antigens. Accordingly, a vaccine challenge with the pneumococcal 23 valent polysaccharide vaccine will likely be abnormal. An abnormal result is defined as an antibody level of < 1.3 mcg/ml in less than 70% of the serotypes. This should be measured at least 1 month after the vaccine administration.
References
Knutsen A. IgG subclass deficiency. In: UpToDate, Post TW (Ed), Wolters Kluwer. https://www.uptodate.com (Accessed on March 8, 2023.), Petrak, R. IgG Subclass Deficiency; Priv Pract Inf Disease (in review)
80%
4 / 5
A 39 y/o woman presents for ID evaluation. She has a history of recurrent herpes simplex meningitis and bronchospastic illness. The most likely IgG subclass deficiency responsible for this clinical presentation is:
Explanation : IgG 3 deficiency is associated with bronchospastic illness, recurrent HSV infections including recurrent lymphocytic meningitis, and recurrent erysipelas. IgG 2 deficiency is associated with numerous other disorders, including SLE, juvenile diabetes, Ataxia telangiectasia, growth hormone deficiency, and allergic colitis.
References
Knutsen A. IgG subclass deficiency. In: UpToDate, Post TW (Ed), Wolters Kluwer. https://www.uptodate.com (Accessed on March 8, 2023.), Petrak, R. IgG Subclass Deficiency; Priv Pract Inf Disease (in review)
100%
5 / 5
A patient presents with an isolated IgG 1 deficiency. Which of the following is also likely to be true?
Explanation : Isolated IgG 1 deficiency is rare. Most patients who present with this disorder also have generalized hypogammaglobulinemia and may evolve into Common Variable Immune Deficiency
References
Knutsen A. IgG subclass deficiency. In: UpToDate, Post TW (Ed), Wolters Kluwer. https://www.uptodate.com (Accessed on March 8, 2023.), Petrak, R. IgG Subclass Deficiency; Priv Pract Inf Disease (in review)
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